Researching and Developing Effective Topical Anti Inflammatories

Inflammatory skin disorders such as rosacea, psoriasis atopic and seborrheic dermatitis are quite common and range from occasional rashes, skin itching, redness to even more chronic conditions. Naturally occurring antioxidants have anti-inflammatory activities simply because of their ability to:

  • Inactivate free radicals/reactive oxygen species (ROS)

  • Inhibit the ROS-mediated stimulation of signaling pathways that can lead to the activation of inflammatory and aging genes such as:   

  1. MMPs  

  2. IL-1

  3. COX-2 

  4. TNF-alpha

  5. Interferes directly with receptor activation (signaling pathways that stimulate the inflammatory genes) 

  6. Prevent free radical-induced changes to proteins and to membrane lipids that destroy their normal cellular functions

With all of the negative side effects of prescription anti-inflammatories on the market, there has been an increased interest in pharmaceutical and cosmetics companies to research and identify naturally derived botanicals to treat inflammatory skin conditions. Corticosteroids and immunosuppressive drugs like Elidel® and Protopic® are common anti-inflammatory prescriptions; however, they cause the undesirable side effects of suppressing the immune system and thinning the skin.

There are many natural compounds and oxidants such as 4-propyl guaiacol, curcumin, luteolin, C ferulic acid, genistein, and epigallocatechin gallate, all which have been shown to have anti-inflammatory actives. Although each has shown some results, they are not necessarily desirable in skin care products because of they're overpowering scents and pronounced yellow, brown or red colors which have shown to stain skin.

Lorenol Labs® has identified naturally derived botanicals such as sulforaphane and other natural compounds combined which has been named LORENOL®LORENOL® has the ability to interrupt one or more steps in the inflammatory process helping to improve inflammatory skin conditions. This combination of natural botanicals not only possesses strong anti-inflammatory actives but has also shown excellent anti-aging benefits. This particular combination of compounds has the ability to interrupt IL-1 from becoming active, which is well known as a primary cause of skin aging. LORENOL® has the ability to interrupt one or more steps in the inflammatory process which help to improve inflammatory conditions. The company research screening process includes human cell cultures and (FRANZ testing) which includes human keratinocytes, fibroblasts, melanocytes, endothelial cells, monocytes, and T-lymphocytes.  Results have shown the effect of the actives in LORENOL® to be a multi-functional synergistic blend of anti-irritants and anti-inflammatory properties that include:

  • 2nd generation of soothing agents 

  • Natural proprietary ingredients including Zingiber Officinalis, Alovsia Citodora, and Sulforaphane 

  • Proven synergistic anti-irritant and antimicrobial efficacy

  • A comprehensive solution for targeting all major inflammatory mediators

  • Triple anti-irritant efficacy, effective interrupter of  IL-1α, TNF α, COX-2 & PGE2 (in vitro) which; 

  • visibly reduces redness and blotchiness protects the skin from daily aggressors that cause signs of premature aging