© Copyright 2019 Lorenol Labs, LLC 

How does LORENOL work? 

LORENOL™  follows the Dalton 500 rule for penetration of effective actives to create effective skin care. 


Dalton 500 RULE



Substances smaller than 500 kDa, with sufficient oil solubility and high partition coefficient, can be absorbed into the skin. However, in contrast, larger molecules (molecular weight > 500 kDa) cannot pass the cutaneous barrier. (Bos JD, Meinardi MMHM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000; 9:165–169.) 


There are 3 pathways into the skin: 

  1. The Intercellular pathway, which is through lipid matrix between keratinocytes (the 'mortar').

  2. The Transcellular pathway, which is through the keratinocytes.

  3. The Transappendageal pathway, across hair follicles, sebaceous glands and sweat glands. The Transappendageal pathway is NOT a major penetration pathway as it covers only 0.1% of the skin surface area.  Permeation in the skin is mainly through the lipid matrix of the 'Stratum Corneum' (Hadgraft J. Modulation of the barrier function of the skin. Skin Pharmacol Appl Skin Physiol. 2001; 14:72–81.) 


How do we know LORENOLwill penetrate the skin?

  1. LORENOL™  has multi-functional active ingredients

  2. The MW (molecular weight) of LORENOL™ is 177 

  3. LORENOL™ is oil based - oil penetrates skin

  4. LORENOL™ is a natural product, and not chemically altered

  5. Testing is performed through Franz Testing to ensure efficacy


Laser Resurfacing and The Wound Healing Process

Ablative laser treatments, whether flat beam or fractional, will result in a 'wounding' of the skin tissue. These procedures are commonly used to trigger a wound healing process which can result in a younger and more refreshed look to aging skin.


The following provides detailed information concerning the process of laser procedures and what happens to the skin after a procedure. 


There are three separate phases of the wound healing process following a laser procedure:


Phase 1 - Inflammatory

Typically, wounds from cuts, abrasions, or breaks in the skin will last approximately 48 hours.


Phase 2  - Proliferative or Rebuilding

During this healing and rebuilding phase, neutrophils, monocytes and macrophages move into the site and scavenge debris from the tissue while killing infectious organisms.  


Phase 3 -  Remodeling 

During this time free radicals are produced in immune cells. (These are referred to as MMP’s). These MMP’s (elastase, collagenase, and inflammatory mediators such as TNF-a, IL1, & PGE-2 will become present in the skin). Unfortunately, as long as these inflammatory mediators are present in the skin, the rebuilding phase WILL NOT/CANNOT begin.